PPIP5K1

Across TCGA cell cohorts, PPIP5K1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPIP5K1-associated genes across cancer lineages are NXNL1, PSAPL1, and MAGEB4. Each is linked with PPIP5K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIP5K1-to-partner and partner-to-PPIP5K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXNL1 grouped by PPIP5K1-low versus PPIP5K1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIP5K1→partner) and Y-score (partner→PPIP5K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NXNL1 →	+0.024	+5.228	.004	.005	3	1
BLOOD_Leukemia	PSAPL1 →	+0.052	+4.922	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

NXNL1 by PPIP5K1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →