PPIL4

Across TCGA patient cohorts, PPIL4 mutation is significantly associated with the RNA expression of many other genes, with 1,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIL4-associated genes across cancer lineages are RN7SL248P, MIR4252, and TRAJ47. Each is linked with PPIL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIL4-to-partner and partner-to-PPIL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by PPIL4-low versus PPIL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL4→partner) and Y-score (partner→PPIL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.046	+2.783	<.001	.009	3	2
LUAD	MIR4252 →	+0.815	+5.712	<.001	.003	3	2
UCEC	TRAJ47 →	+0.424	+1.935	<.001	.002	3	2
UCEC	TRAJ11 →	+0.467	+1.895	<.001	.002	3	2
UCEC	IGHJ1 →	+1.333	+1.736	.005	.007	3	2
UCEC	RNA5SP437 →	+0.302	+1.593	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,948 associations by consensus.

RN7SL248P by PPIL4 expression — UCEC

Explore this box plot interactively →