PPIL3

Across TCGA patient cohorts, PPIL3 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIL3-associated genes across cancer lineages are FOXO3a_pS318_S321, p38-MAPK_pT180_Y182, and STAT3_pY705. Each is linked with PPIL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIL3-to-partner and partner-to-PPIL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PPIL3-low versus PPIL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL3→partner) and Y-score (partner→PPIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.144	-3.160	.027	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.487	-3.169	.039	.019	3	1
UCEC	STAT3_pY705 →	-0.456	-2.990	<.001	.036	3	1
UCEC	C-Raf_pS338 →	-0.092	-3.321	.031	.010	3	1
UCEC	DJ-1 →	+0.187	+3.000	.032	.036	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FOXO3a_pS318_S321 by PPIL3 expression — UCEC

Explore this box plot interactively →