PPIL3

Across TCGA pan-cancer cohorts, PPIL3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPIL3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPIL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIL3 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, LIHC, and KICH are the cancer types where PPIL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.762	<.001	11	view →
LIHC	All	III,IV	+1.107	<.001	9	view →
KICH	Female	II,III,IV	−1.654	<.001	8	view →
COAD	Male	All	+0.616	<.001	8	view →
CHOL	All	All	+1.443	<.001	5	view →
LUAD	Female	All	+0.442	<.001	5	view →
ESCA	All	All	+0.528	.012	4	view →
LUSC	All	All	+0.408	.002	3	view →
READ	All	All	+0.568	.011	2	view →
HNSC	Male	III,IV	+0.425	.026	2	view →
UCEC	All	All	−0.311	.044	2	view →
KIRP	All	II,III,IV	+0.391	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPIL3–KIRC

Open the KIRC breakdown →