PPIL3

Across TCGA cell cohorts, PPIL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,807 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPIL3-associated GO terms across cancer lineages are Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Nucleotide-excision repair, and Regulation of tRNA catabolic process. Each is linked with PPIL3 in more than 7 cancer types. Because this analysis shows association rather than direction, both PPIL3-to-partner and partner-to-PPIL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by PPIL3-low versus PPIL3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL3→partner) and Y-score (partner→PPIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.103	-0.505	<.001	.005	3	8
BLOOD_Myeloma	Nucleotide-excision repair →	+0.043	+0.742	<.001	<.001	3	8
BONE	Regulation of tRNA catabolic process →	-0.134	-0.488	.005	.006	3	7
BONE	Negative regulation of tRNA catabolic process →	-0.134	-0.488	.005	.006	3	7
BONE	Regulation of tRNA stability →	-0.134	-0.488	.005	.006	3	7
BONE	tRNA stabilization →	-0.134	-0.488	.005	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,807 associations by consensus.

Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by PPIL3 expression — PANCREAS

Explore this box plot interactively →