PPIL1

Across TCGA patient cohorts, PPIL1 mutation is significantly associated with the RNA expression of many other genes, with 826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIL1-associated genes across cancer lineages are TRDV3, GTF3AP1, and OR2T33. Each is linked with PPIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIL1-to-partner and partner-to-PPIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDV3 grouped by PPIL1-low versus PPIL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL1→partner) and Y-score (partner→PPIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRDV3 →	+0.307	+2.636	<.001	<.001	3	2
SKCM	GTF3AP1 →	+0.068	+4.665	<.001	<.001	3	2
SKCM	OR2T33 →	+0.118	+3.823	<.001	.001	3	1
SKCM	RNA5SP188 →	+0.284	+4.147	<.001	.008	3	1
SKCM	RNA5SP90 →	+0.322	+3.454	<.001	.006	3	1
SKCM	SLC35C2P1 →	+0.033	+3.508	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 826 associations by consensus.

TRDV3 by PPIL1 expression — UCEC

Explore this box plot interactively →