PPIF

Across TCGA pan-cancer cohorts, PPIF mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPIF data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PPIF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPIF expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where PPIF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	1.000	0.794	.004	17	view →
HNSC	DFS	Quartile	IV	1.000	0.568	.004	16	view →
CCRCC	DFS	Median	III,IV	0.409	0.715	.008	13	view →
LUAD	OS	Quartile	II,III,IV	0.363	1.000	.020	9	view →
PDAC	DFS	Median	All	0.864	0.730	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPIF–LSCC (DFS)

Open the LSCC breakdown →