PPIEL

Across TCGA patient cohorts, PPIEL mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIEL-associated genes across cancer lineages are MIR4744, MIR7702, and OR7E31P. Each is linked with PPIEL in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIEL-to-partner and partner-to-PPIEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4744 grouped by PPIEL-low versus PPIEL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIEL→partner) and Y-score (partner→PPIEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4744 →	+0.942	+4.863	<.001	<.001	3	1
UCEC	MIR7702 →	+0.757	+6.475	<.001	<.001	3	1
UCEC	OR7E31P →	+0.129	+4.184	.001	.004	3	1
UCEC	LCE1E →	+0.095	+4.838	.007	<.001	3	1
UCEC	MIR425 →	+0.809	+4.914	<.001	<.001	3	1
UCEC	RNY4P14 →	+0.396	+5.137	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MIR4744 by PPIEL expression — UCEC

Explore this box plot interactively →