PPIE

Across TCGA pan-cancer cohorts, PPIE mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPIE data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPIE mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPIE expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where PPIE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.296	1.000	.003	34	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	24	view →
GBM	OS	Median	All	0.542	0.232	.010	12	view →
LUAD	DFS	Median	All	0.448	0.722	.006	7	view →
CCRCC	OS	Quartile	II,III,IV	0.409	0.865	.019	2	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.926	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPIE–HNSC (OS)

Open the HNSC breakdown →