PPIE

Across TCGA patient cohorts, PPIE RNA expression is significantly associated with the protein abundance of many other proteins, with 9,899 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPIE-associated proteins across cancer lineages are PUM1, RCC2, and SFPQ. Each is linked with PPIE in more than 4 cancer types. Because this analysis shows association rather than direction, both PPIE-to-partner and partner-to-PPIE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPIE versus PUM1 in UCEC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIE→partner) and Y-score (partner→PPIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PUM1 →	+0.221	+0.398	<.001	.001	3	5
LSCC	RCC2 →	+0.475	+0.453	<.001	<.001	3	5
GBM	SFPQ →	+0.302	+0.299	<.001	<.001	3	5
BRCA	PPIH →	+0.353	+0.511	<.001	<.001	3	5
GBM	SNRNP200 →	+0.326	+0.349	<.001	<.001	3	5
GBM	SCAF8 →	+0.200	+0.269	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,899 associations by consensus.

PPIE vs PUM1 — UCEC

Explore this scatter interactively →