PPIE

Across TCGA patient cohorts, PPIE protein abundance is significantly associated with the RNA expression of many other genes, with 12,867 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPIE-associated genes across cancer lineages are RFC5, C1orf109, and NEK2. Each is linked with PPIE in more than 6 cancer types. Because this analysis shows association rather than direction, both PPIE-to-partner and partner-to-PPIE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPIE versus RFC5 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIE→partner) and Y-score (partner→PPIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC5 →	+0.520	+0.230	<.001	<.001	3	7
LSCC	C1orf109 →	+0.579	+0.346	<.001	<.001	3	7
UCEC	NEK2 →	+1.118	+0.151	<.001	.001	3	6
UCEC	CDCA8 →	+1.479	+0.232	<.001	<.001	3	6
LSCC	USP21 →	+0.551	+0.291	.002	.001	3	6
GBM	PPIH →	+0.460	+0.424	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,867 associations by consensus.

PPIE vs RFC5 — LSCC

Explore this scatter interactively →