PPIE

Across TCGA patient cohorts, PPIE mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIE-associated genes across cancer lineages are YAP, EGFR_pY1068, and EGFR. Each is linked with PPIE in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIE-to-partner and partner-to-PPIE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP grouped by PPIE-low versus PPIE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIE→partner) and Y-score (partner→PPIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YAP →	+0.143	+2.415	.017	.003	3	2
UCEC	EGFR_pY1068 →	-0.211	-2.999	.036	.035	3	1
UCEC	EGFR →	-0.171	-3.000	.007	.036	3	1
UCEC	A-Raf_pS299 →	-0.110	-2.000	.021	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.158	-2.321	.019	.034	3	1
UCEC	MEK1 →	+0.465	+2.415	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

YAP by PPIE expression — UCEC

Explore this box plot interactively →