PPIE

Across TCGA cell cohorts, PPIE RNA expression is significantly associated with the go_rna of many other GO terms, with 2,827 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPIE-associated GO terms across cancer lineages are Protein localization to nucleus, snRNA processing, and RNA polymerase II preinitiation complex assembly. Each is linked with PPIE in more than 11 cancer types. Because this analysis shows association rather than direction, both PPIE-to-partner and partner-to-PPIE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nucleus grouped by PPIE-low versus PPIE-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIE→partner) and Y-score (partner→PPIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein localization to nucleus →	+0.050	+1.042	.006	.002	3	12
BONE	snRNA processing →	+0.091	+0.467	<.001	.001	3	11
LIVER	RNA polymerase II preinitiation complex assembly →	+0.070	+0.752	.006	.005	3	10
BLOOD_Leukemia	Positive regulation of mitotic cell cycle phase transition →	+0.076	+0.493	<.001	.001	3	9
BONE	Negative regulation of protein modification by small protein conjugation or removal →	+0.064	+0.386	<.001	<.001	3	9
SKIN	Translational initiation →	+0.085	+0.627	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,827 associations by consensus.

Protein localization to nucleus by PPIE expression — LUNG_NSCLC_LUSC

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