PPID

Across TCGA patient cohorts, PPID RNA expression is significantly associated with the mutation status of many other genes, with 10,259 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPID-associated genes across cancer lineages are FAT4, DNAH10, and PCDHA3. Each is linked with PPID in more than 4 cancer types. Because this analysis shows association rather than direction, both PPID-to-partner and partner-to-PPID results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAT4 grouped by PPID-low versus PPID-high in STAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPID→partner) and Y-score (partner→PPID) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FAT4 →	+1.431	+0.305	.003	<.001	3	5
STAD	DNAH10 →	+1.999	+0.402	.002	.001	3	5
STAD	PCDHA3 →	+3.484	+0.461	.002	.004	3	5
UCEC	PREX2 →	+2.617	+0.569	<.001	<.001	3	5
UCEC	CREBBP →	+2.839	+0.501	<.001	<.001	3	4
UCEC	PCDHB12 →	+2.401	+0.561	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,259 associations by consensus.

FAT4 by PPID expression — STAD

Explore this box plot interactively →