PPID

Across TCGA pan-cancer cohorts, PPID RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPID’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PPID RNA is repressed in tumor relative to normal tissue. In most cancer types PPID is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, HNSC, and LUSC are the cancer types where PPID tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPID RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.582	<.001	11	view →
HNSC	All	II,III,IV	+0.388	<.001	8	view →
LUSC	Male	II,III,IV	+0.751	<.001	7	view →
STAD	All	II,III,IV	+0.690	.001	7	view →
LUAD	Male	II,III,IV	+0.570	<.001	6	view →
KIRC	All	All	−0.209	.002	6	view →
KIRP	All	All	−0.353	<.001	4	view →
BRCA	All	II,III,IV	+0.207	<.001	4	view →
BLCA	All	All	+0.333	.045	2	view →
KICH	All	All	−0.323	.017	2	view →
COAD	Male	All	+0.293	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPID–THCA

Open the THCA breakdown →