PPID

Across TCGA patient cohorts, PPID protein abundance is significantly associated with the RNA expression of many other genes, with 8,754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPID-associated genes across cancer lineages are NEIL3, NAA15, and C4orf46. Each is linked with PPID in more than 5 cancer types. Because this analysis shows association rather than direction, both PPID-to-partner and partner-to-PPID results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPID versus NEIL3 in CCRCC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPID→partner) and Y-score (partner→PPID) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NEIL3 →	+0.895	+0.196	<.001	<.001	3	6
LSCC	NAA15 →	+0.502	+0.318	<.001	.002	3	5
BRCA	C4orf46 →	+0.664	+0.377	<.001	<.001	3	5
OV	ARFIP1 →	+0.747	+0.444	<.001	<.001	3	4
LSCC	ABCE1 →	+0.549	+0.357	<.001	<.001	3	4
HNSC	TMA16 →	+0.489	+0.231	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,754 associations by consensus.

PPID vs NEIL3 — CCRCC

Explore this scatter interactively →