PPID

Across TCGA patient cohorts, PPID mutation is significantly associated with the RNA expression of many other genes, with 2,154 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPID-associated genes across cancer lineages are OR5J7P, MIR4516, and SNX18P23. Each is linked with PPID in more than 1 cancer types. Because this analysis shows association rather than direction, both PPID-to-partner and partner-to-PPID results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5J7P grouped by PPID-low versus PPID-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPID→partner) and Y-score (partner→PPID) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR5J7P →	+0.314	+7.741	<.001	.009	3	2
UCEC	MIR4516 →	+0.275	+1.941	<.001	.009	3	2
READ	SNX18P23 →	+0.078	+5.653	<.001	.003	3	2
BRCA	MIR6894 →	+0.708	+5.506	<.001	.005	3	1
SKCM	BTG3P1 →	+0.089	+7.816	<.001	.008	3	1
BLCA	OR11H2 →	+0.056	+5.588	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,154 associations by consensus.

OR5J7P by PPID expression — COAD

Explore this box plot interactively →