PPID

Across TCGA cell cohorts, PPID RNA expression is significantly associated with the go_rna of many other GO terms, with 3,046 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PPID-associated GO terms across cancer lineages are Mitochondrial DNA replication, DNA replication initiation, and Regulation of protein ADP-ribosylation. Each is linked with PPID in more than 12 cancer types. Because this analysis shows association rather than direction, both PPID-to-partner and partner-to-PPID results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial DNA replication grouped by PPID-low versus PPID-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPID→partner) and Y-score (partner→PPID) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Mitochondrial DNA replication →	+0.106	+0.478	<.001	<.001	3	13
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.162	+0.811	.004	.002	3	13
LUNG_SCLC	Regulation of protein ADP-ribosylation →	+0.150	+0.606	<.001	.001	3	12
STOMACH	Pseudouridine synthesis →	+0.098	+0.666	.001	.002	3	12
STOMACH	Positive regulation of centriole replication →	+0.106	+0.526	.001	.006	3	11
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.125	+0.987	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,046 associations by consensus.

Mitochondrial DNA replication by PPID expression — CNS

Explore this box plot interactively →