PPIB

Across TCGA patient cohorts, PPIB mutation is significantly associated with the RNA expression of many other genes, with 400 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIB-associated genes across cancer lineages are MTATP6P29, MRPS18BP2, and RN7SL162P. Each is linked with PPIB in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIB-to-partner and partner-to-PPIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P29 grouped by PPIB-low versus PPIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIB→partner) and Y-score (partner→PPIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTATP6P29 →	+0.329	+3.133	<.001	.002	3	2
UCEC	MRPS18BP2 →	+0.176	+3.156	<.001	<.001	3	2
SKCM	RN7SL162P →	+0.108	+3.237	.008	.001	3	2
BLCA	RNA5SP212 →	+0.568	+6.018	<.001	.002	3	2
BLCA	RN7SL89P →	+0.494	+4.973	<.001	.009	3	2
UCEC	IGHV3OR16-8 →	+0.849	+3.120	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 400 associations by consensus.

MTATP6P29 by PPIB expression — UCEC

Explore this box plot interactively →