PPIAP78

Across TCGA pan-cancer cohorts, PPIAP78 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PPIAP78’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPIAP78 RNA is repressed in tumor relative to normal tissue. In most cancer types PPIAP78 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where PPIAP78 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIAP78 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.535	<.001	12	view →
HNSC	All	III,IV	+0.682	<.001	11	view →
THCA	Male	II,III,IV	−0.440	<.001	9	view →
KICH	Female	All	−0.378	<.001	5	view →
BRCA	Female	All	+0.066	.010	4	view →
KIRP	Female	All	−0.443	.003	3	view →
LUSC	All	All	−0.237	.003	3	view →
UCEC	All	All	−0.222	<.001	2	view →
LIHC	Male	All	+0.122	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PPIAP78–KIRC

Open the KIRC breakdown →