PPIAP58

Across TCGA pan-cancer cohorts, PPIAP58 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PPIAP58 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher PPIAP58 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPIAP58 expression acts as an unfavorable survival marker, although some lineages such as CESC and READ show a favorable association.

UVM, STAD, and UCEC are the cancer types where PPIAP58 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.467	0.854	<.001	89	view →
STAD	DFS	Tertile	II,III,IV	0.335	0.651	.003	44	view →
UCEC	DFS	Quartile	All	0.565	0.782	<.001	38	view →
CESC	OS	Median	All	0.874	0.730	.002	28	view →
READ	DFS	Median	II,III,IV	0.878	0.710	.002	24	view →
ACC	DFS	Tertile	All	0.499	0.761	.009	22	view →
LGG	DFS	Tertile	All	0.761	0.884	<.001	22	view →
BRCA	DFS	Median	III,IV	0.568	0.429	.012	19	view →
THCA	OS	Median	II,III,IV	0.983	0.907	.004	19	view →
COAD	OS	Quartile	III,IV	0.901	0.617	.009	17	view →
GBM	OS	Tertile	All	0.337	0.471	.012	15	view →
LUAD	OS	Quartile	All	0.770	0.900	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PPIAP58–UVM (DFS)

Open the UVM breakdown →