PPIAP49

Across TCGA pan-cancer cohorts, PPIAP49 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PPIAP49 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher PPIAP49 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPIAP49 expression acts as an unfavorable survival marker, although some lineages such as LUSC and CESC show a favorable association.

STAD, UCEC, and LUSC are the cancer types where PPIAP49 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Quartile	II,III,IV	0.355	0.605	<.001	107	view →
UCEC	DFS	Median	All	0.482	0.720	<.001	40	view →
LUSC	OS	Quartile	II,III,IV	0.890	0.716	.010	27	view →
LUAD	OS	Quartile	II,III,IV	0.561	0.750	<.001	26	view →
MESO	OS	Quartile	All	0.388	0.613	.011	12	view →
CESC	DFS	Quartile	II,III,IV	0.809	0.562	.022	12	view →
ACC	OS	Median	IV	0.753	0.344	.009	12	view →
LGG	DFS	Quartile	All	0.631	0.758	.006	11	view →
READ	DFS	Median	IV	0.936	0.179	.010	11	view →
SKCM	OS	Median	III,IV	0.522	0.274	.003	10	view →
PCPG	DFS	Median	All	1.000	0.828	.008	8	view →
CHOL	DFS	Tertile	II,III,IV	0.119	0.488	.044	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PPIAP49–STAD (DFS)

Open the STAD breakdown →