PPIAP49

Across TCGA pan-cancer cohorts, PPIAP49 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPIAP49’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PPIAP49 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIAP49 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

LUAD, HNSC, and LIHC are the cancer types where PPIAP49 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIAP49 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.100	.006	6	view →
HNSC	Male	All	+0.100	.011	4	view →
LIHC	All	All	+0.040	.013	3	view →
PAAD	Female	All	−0.195	.049	2	view →
KICH	Female	II,III,IV	+0.102	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPIAP49–LUAD

Open the LUAD breakdown →