PPIAP26

Across TCGA pan-cancer cohorts, PPIAP26 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PPIAP26’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPIAP26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIAP26 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where PPIAP26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIAP26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.568	<.001	12	view →
THCA	All	All	−0.862	<.001	9	view →
LIHC	All	All	+0.044	<.001	4	view →
LUSC	All	All	+0.381	.002	3	view →
BRCA	All	II,III,IV	+0.044	.021	2	view →
READ	All	All	+0.237	.041	1	view →
LUAD	All	All	+0.192	.024	1	view →
COAD	All	II,III,IV	+0.141	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PPIAP26–HNSC

Open the HNSC breakdown →