PPIAP14

Across TCGA pan-cancer cohorts, PPIAP14 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PPIAP14 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PPIAP14 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPIAP14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

ACC, KIRC, and SKCM are the cancer types where PPIAP14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.754	0.948	.001	68	view →
KIRC	DFS	Median	All	0.839	0.902	<.001	50	view →
SKCM	DFS	Tertile	II,III,IV	0.610	0.773	.007	37	view →
STAD	DFS	Median	II,III,IV	0.487	0.589	.018	25	view →
COAD	OS	Quartile	IV	0.363	0.823	.003	24	view →
UCEC	DFS	Median	All	0.516	0.791	<.001	24	view →
LUAD	DFS	Quartile	III,IV	0.308	0.687	.014	17	view →
HNSC	OS	Tertile	III,IV	0.813	0.656	.008	17	view →
LUSC	OS	Median	III,IV	0.271	0.743	.018	15	view →
CESC	OS	Median	II,III,IV	0.725	0.387	.013	12	view →
BRCA	OS	Median	All	0.638	0.533	.017	11	view →
LGG	OS	Quartile	All	0.753	0.849	.026	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PPIAP14–ACC (OS)

Open the ACC breakdown →