Across TCGA patient cohorts, PPIA mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIA-associated genes across cancer lineages are CCDC103, SMIM28, and LINC02210-CRHR1. Each is linked with PPIA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIA-to-partner and partner-to-PPIA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIA→partner) and Y-score (partner→PPIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC103 →	+0.031	+3.884	.005	.001	3	1
UCEC	SMIM28 →	+0.537	+2.770	<.001	.008	3	1
UCEC	LINC02210-CRHR1 →	+0.180	+3.437	<.001	.001	3	1
UCEC	GRAPL →	+0.121	+3.784	<.001	.002	3	1
UCEC	LINC00523 →	+0.257	+2.574	.007	.009	3	1
UCEC	RNU5E-10P →	+0.658	+3.043	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

PPIA survival (RNA) · tumor vs normal (RNA) · all PPIA data types