PPHLN1

Across TCGA patient cohorts, PPHLN1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,241 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPHLN1-associated genes across cancer lineages are MPHOSPH9, TOP2A, and SPPL3. Each is linked with PPHLN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PPHLN1-to-partner and partner-to-PPHLN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPHLN1 versus MPHOSPH9 in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPHLN1→partner) and Y-score (partner→PPHLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MPHOSPH9 →	+0.740	+0.208	<.001	<.001	3	6
HNSC	TOP2A →	+1.276	+0.165	.001	.001	3	5
LSCC	SPPL3 →	+0.598	+0.224	<.001	<.001	3	5
LSCC	RFC5 →	+0.776	+0.200	<.001	<.001	3	5
HNSC	TMPO →	+0.996	+0.216	<.001	<.001	3	5
LSCC	NEMP1 →	+0.819	+0.263	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,241 associations by consensus.

PPHLN1 vs MPHOSPH9 — HNSC

Explore this scatter interactively →