PPFIBP2

Across TCGA patient cohorts, PPFIBP2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,129 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PPFIBP2-associated genes across cancer lineages are CYB5R2, SLC22A18, and RPS6KA1. Each is linked with PPFIBP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PPFIBP2-to-partner and partner-to-PPFIBP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPFIBP2 versus CYB5R2 in BRCA, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIBP2→partner) and Y-score (partner→PPFIBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CYB5R2 →	+0.771	+0.287	<.001	<.001	3	7
LUAD	SLC22A18 →	+0.807	+0.356	<.001	<.001	3	5
UCEC	RPS6KA1 →	+0.814	+0.223	.001	.002	3	4
UCEC	TRPM4 →	+0.916	+0.332	<.001	.001	3	4
HNSC	GLTP →	+1.317	+0.441	<.001	<.001	3	4
UCEC	RHOBTB3 →	-1.036	-0.224	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,129 associations by consensus.

PPFIBP2 vs CYB5R2 — BRCA

Explore this scatter interactively →