PPFIA2-AS1

Across TCGA pan-cancer cohorts, PPFIA2-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PPFIA2-AS1 data layer.

The strongest signal is observed in thymoma (THYM), where higher PPFIA2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPFIA2-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCS show a favorable association.

THYM, ESCA, and DLBC are the cancer types where PPFIA2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	All	0.511	0.809	<.001	60	view →
ESCA	DFS	Quartile	II,III,IV	0.702	0.479	.017	19	view →
DLBC	DFS	Tertile	IV	0.260	0.885	.003	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
UCS	DFS	Tertile	II,III,IV	0.532	0.184	.019	14	view →
UVM	OS	Tertile	All	0.379	0.727	.029	12	view →
KIRP	DFS	Tertile	IV	0.761	0.044	.031	12	view →
READ	DFS	Quartile	All	0.238	0.670	.005	12	view →
LGG	OS	Median	All	0.654	0.369	<.001	11	view →
COAD	OS	Tertile	IV	0.844	0.326	.032	9	view →
LIHC	DFS	Tertile	All	0.162	0.325	.021	7	view →
PRAD	DFS	Median	All	0.911	0.954	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PPFIA2-AS1–THYM (DFS)

Open the THYM breakdown →