PPFIA2-AS1

Across TCGA pan-cancer cohorts, PPFIA2-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PPFIA2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPFIA2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PPFIA2-AS1 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, LUSC, and KIRP are the cancer types where PPFIA2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPFIA2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.041	.001	8	view →
LUSC	Female	All	−0.077	<.001	7	view →
KIRP	All	All	−0.077	<.001	7	view →
COAD	Male	IV	−0.052	.008	3	view →
HNSC	Female	II,III,IV	+0.021	.020	3	view →
BRCA	All	III,IV	−0.051	.047	2	view →
THCA	All	All	−0.028	.018	2	view →
ESCA	Female	All	−0.100	.008	1	view →
LIHC	Male	All	+0.032	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PPFIA2-AS1–KIRC

Open the KIRC breakdown →