PPFIA1

Across TCGA cell cohorts, PPFIA1 mutation is significantly associated with the RNA expression of many other genes, with 438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPFIA1-associated genes across cancer lineages are GRPEL2, KHDC3L, and PCCB. Each is linked with PPFIA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPFIA1-to-partner and partner-to-PPFIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRPEL2 grouped by PPFIA1-low versus PPFIA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA1→partner) and Y-score (partner→PPFIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GRPEL2 →	+0.564	+3.614	.009	<.001	3	2
BLOOD_Leukemia	KHDC3L →	+0.143	+3.481	<.001	<.001	3	2
LARGE_INTESTINE	PCCB →	+0.558	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	HPSE →	+1.026	+3.321	.001	.003	3	2
LARGE_INTESTINE	CNTLN →	+0.860	+2.043	.004	.008	3	2
SKIN	CIB4 →	+0.036	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 438 associations by consensus.

GRPEL2 by PPFIA1 expression — BLOOD_Leukemia

Explore this box plot interactively →