PPEF2

Across TCGA pan-cancer cohorts, PPEF2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPEF2 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PPEF2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPEF2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

COAD, UCEC, and READ are the cancer types where PPEF2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.575	0.873	<.001	30	view →
UCEC	DFS	Median	All	0.974	0.616	.003	26	view →
READ	OS	Median	All	0.198	0.829	.001	20	view →
SKCM	DFS	Median	III,IV	0.883	0.189	.002	13	view →
OV	OS	Median	IV	0.076	0.759	.014	12	view →
LIHC	OS	Median	II,III,IV	0.232	0.718	.002	12	view →
LUAD	OS	Median	III,IV	0.083	0.680	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPEF2–COAD (OS)

Open the COAD breakdown →