PPEF2

Across TCGA patient cohorts, PPEF2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPEF2-associated genes across cancer lineages are C-Raf, Notch1, and Rab11. Each is linked with PPEF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPEF2-to-partner and partner-to-PPEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PPEF2-low versus PPEF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPEF2→partner) and Y-score (partner→PPEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.146	+1.807	<.001	<.001	3	4
STAD	Notch1 →	+0.202	+3.021	.020	.018	3	3
UCEC	Rab11 →	-0.093	-1.378	.031	.008	3	3
UCEC	TFRC →	+0.453	+1.378	.004	.008	3	3
UCEC	Caspase-7-cleavedD198 →	+0.422	+1.604	.017	.010	3	3
LUAD	p70-S6K →	+0.246	+3.000	.035	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

C-Raf by PPEF2 expression — UCEC

Explore this box plot interactively →