PPEF2

Across TCGA cell cohorts, PPEF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,187 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPEF2-associated GO terms across cancer lineages are Electron transport chain, Negative regulation of macroautophagy, and Regulation of mRNA splicing, via spliceosome. Each is linked with PPEF2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PPEF2-to-partner and partner-to-PPEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Electron transport chain grouped by PPEF2-low versus PPEF2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPEF2→partner) and Y-score (partner→PPEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Electron transport chain →	+0.046	+0.008	.002	.004	3	5
BONE	Negative regulation of macroautophagy →	+0.049	+0.043	.002	.007	3	5
BLOOD_Leukemia	Regulation of mRNA splicing, via spliceosome →	+0.053	+0.057	<.001	.007	3	4
BLOOD_Leukemia	DNA methylation-dependent constitutive heterochromatin formation →	+0.107	+0.085	.001	.001	3	4
SKIN	Respiratory electron transport chain →	+0.044	+0.007	.006	.007	3	4
BONE	Fatty acid derivative catabolic process →	-0.081	-0.032	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,187 associations by consensus.

Electron transport chain by PPEF2 expression — SKIN

Explore this box plot interactively →