PPEF1

Across TCGA patient cohorts, PPEF1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPEF1-associated genes across cancer lineages are 4E-BP1, MEK1, and RAD51. Each is linked with PPEF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPEF1-to-partner and partner-to-PPEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PPEF1-low versus PPEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPEF1→partner) and Y-score (partner→PPEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.249	+1.906	.003	.014	3	3
UCEC	MEK1 →	+0.423	+1.893	<.001	<.001	3	2
COAD	RAD51 →	+0.218	+3.008	.007	.019	3	2
COAD	TSC1 →	-0.543	-2.991	<.001	.036	3	2
UCEC	Ku80 →	+0.168	+1.013	.021	.047	3	2
UCEC	Src_pY416 →	-0.192	-2.195	.010	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

4E-BP1 by PPEF1 expression — UCEC

Explore this box plot interactively →