PPEF1

Across TCGA pan-cancer cohorts, PPEF1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PPEF1 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PPEF1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPEF1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and LUSC show a favorable association.

KIRP, ACC, and UVM are the cancer types where PPEF1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.784	0.934	<.001	151	view →
ACC	OS	Median	II,III,IV	0.614	0.905	<.001	114	view →
UVM	DFS	Quartile	All	0.239	0.739	<.001	109	view →
STAD	OS	Tertile	III,IV	0.384	0.664	<.001	98	view →
KICH	DFS	Quartile	II,III,IV	0.376	0.894	.002	76	view →
BLCA	OS	Quartile	II,III,IV	0.351	0.688	.016	27	view →
THCA	DFS	Median	II,III,IV	0.602	0.869	.001	26	view →
MESO	OS	Tertile	III,IV	0.332	0.583	.008	26	view →
UCS	OS	Median	IV	0.302	0.817	.002	24	view →
SARC	DFS	Tertile	All	0.493	0.670	.001	17	view →
SKCM	OS	Quartile	All	0.697	0.830	.001	14	view →
GBM	OS	Median	All	0.335	0.470	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PPEF1–KIRP (DFS)

Open the KIRP breakdown →