PPEF1

Across TCGA cell cohorts, PPEF1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PPEF1-associated genes across cancer lineages are OR10H5, OR2A5, and C16orf82. Each is linked with PPEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPEF1-to-partner and partner-to-PPEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10H5 grouped by PPEF1-low versus PPEF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPEF1→partner) and Y-score (partner→PPEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1
SKIN	OR2A5 →	+0.103	+4.977	<.001	.007	3	1
SKIN	C16orf82 →	+0.016	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	TCP10L2 →	+0.078	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	WFDC6 →	+0.057	+4.887	<.001	.009	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR10H5 by PPEF1 expression — SKIN

Explore this box plot interactively →