PPDPF

Across TCGA pan-cancer cohorts, PPDPF Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPDPF data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PPDPF Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPDPF expression acts as an unfavorable survival marker.

SKCM, SCLC, and BRCA are the cancer types where PPDPF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.072	0.877	<.001	36	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	18	view →
BRCA	OS	Median	All	0.714	0.963	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PPDPF–SKCM (OS)

Open the SKCM breakdown →