PPDPF

Across TCGA pan-cancer cohorts, PPDPF RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPDPF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PPDPF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPDPF is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

KIRP, BRCA, and CHOL are the cancer types where PPDPF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPDPF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.672	.001	8	view →
BRCA	All	III,IV	+1.150	<.001	6	view →
CHOL	Male	All	+2.910	<.001	5	view →
LIHC	Female	All	+1.804	<.001	4	view →
PAAD	Female	All	+1.269	.009	4	view →
KIRC	Female	All	+0.382	.015	3	view →
THCA	All	All	+0.253	.010	3	view →
LUAD	Male	III,IV	−0.503	.011	2	view →
KICH	Female	II,III,IV	+0.612	.046	1	view →
HNSC	Female	III,IV	−0.571	.048	1	view →
COAD	All	II,III,IV	+0.279	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPDPF–KIRP

Open the KIRP breakdown →