PPDPF

Across TCGA pan-cancer cohorts, PPDPF mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPDPF data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPDPF mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPDPF expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where PPDPF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.969	0.681	.005	14	view →
CCRCC	OS	Quartile	All	1.000	0.823	.014	11	view →
UCEC	DFS	Tertile	All	0.854	1.000	.038	10	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	8	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.435	.023	4	view →
LSCC	DFS	Median	All	0.560	0.991	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPDPF–HNSC (OS)

Open the HNSC breakdown →