PPBP

Across TCGA patient cohorts, PPBP mutation is significantly associated with the RNA expression of many other genes, with 1,340 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPBP-associated genes across cancer lineages are RNF19BPY, RNA5SP96, and ERVE-1. Each is linked with PPBP in more than 2 cancer types. Because this analysis shows association rather than direction, both PPBP-to-partner and partner-to-PPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF19BPY grouped by PPBP-low versus PPBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPBP→partner) and Y-score (partner→PPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNF19BPY →	+0.026	+4.601	<.001	.003	3	3
LUAD	RNA5SP96 →	+0.258	+4.612	.001	.006	3	2
UCEC	ERVE-1 →	+0.585	+3.217	.004	.009	3	2
UCEC	SSRP1 →	+0.597	+3.354	.008	.005	3	1
UCEC	CHEK1 →	+0.935	+3.606	<.001	.001	3	1
UCEC	DSN1 →	+0.630	+3.329	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,340 associations by consensus.

RNF19BPY by PPBP expression — UCEC

Explore this box plot interactively →