PPBP

Across TCGA pan-cancer cohorts, PPBP RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PPBP data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher PPBP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPBP expression acts as an unfavorable survival marker, although some lineages such as UCS and CHOL show a favorable association.

THCA, SCLC, and ACC are the cancer types where PPBP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	0.895	0.988	.008	43	view →
SCLC	OS	Median	All	0.499	0.776	.001	43	view →
ACC	OS	Quartile	II,III,IV	0.689	0.923	.008	37	view →
LAML	DFS	Median	All	0.227	0.552	.001	36	view →
SARC	DFS	Tertile	All	0.370	0.610	<.001	32	view →
SKCM	OS	Median	All	0.691	0.858	<.001	27	view →
KIRP	DFS	Median	All	0.795	0.959	.015	24	view →
KICH	DFS	Quartile	II,III,IV	0.659	1.000	.008	22	view →
BRCA	DFS	Quartile	III,IV	0.785	0.915	.002	21	view →
MESO	OS	Tertile	All	0.294	0.509	.009	20	view →
COAD	OS	Median	III,IV	0.685	0.875	.005	19	view →
UVM	DFS	Median	All	0.523	0.867	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PPBP–THCA (OS)

Open the THCA breakdown →