PPBP

Across TCGA patient cohorts, PPBP mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPBP-associated genes across cancer lineages are Caspase-8, eIF4G, and Heregulin. Each is linked with PPBP in more than 1 cancer types. Because this analysis shows association rather than direction, both PPBP-to-partner and partner-to-PPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by PPBP-low versus PPBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPBP→partner) and Y-score (partner→PPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.301	-3.169	.029	.020	3	1
UCEC	eIF4G →	+0.347	+3.169	.041	.020	2	1
UCEC	Heregulin →	-0.174	-3.000	.010	.036	2	1
UCEC	JNK2 →	+0.223	+2.817	.040	.036	2	1
UCEC	Tuberin →	+0.352	+3.009	.017	.019	2	1
UCEC	BRD4 →	+0.368	+3.007	.017	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Caspase-8 by PPBP expression — UCEC

Explore this box plot interactively →