PPBP

Across TCGA cell cohorts, PPBP RNA expression is significantly associated with the go_rna of many other GO terms, with 1,255 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPBP-associated GO terms across cancer lineages are Vertebrate eye-specific patterning, Response to tumor necrosis factor, and Positive regulation of iron ion transport. Each is linked with PPBP in more than 4 cancer types. Because this analysis shows association rather than direction, both PPBP-to-partner and partner-to-PPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vertebrate eye-specific patterning grouped by PPBP-low versus PPBP-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPBP→partner) and Y-score (partner→PPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Vertebrate eye-specific patterning →	+1.095	+0.938	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Response to tumor necrosis factor →	+0.078	+0.675	<.001	.003	3	5
LUNG_NSCLC_LUAD	Positive regulation of iron ion transport →	+0.823	+1.481	.008	.003	3	5
LUNG_NSCLC_LUAD	Positive regulation of iron ion transmembrane transport →	+0.823	+1.481	.008	.003	3	5
PANCREAS	Complement-mediated synapse pruning →	+0.946	+0.694	.001	.001	3	4
PANCREAS	Response to glucocorticoid →	+0.062	+0.680	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,255 associations by consensus.

Vertebrate eye-specific patterning by PPBP expression — PANCREAS

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