PPAT

Across TCGA patient cohorts, PPAT mutation is significantly associated with the RNA expression of many other genes, with 2,217 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPAT-associated genes across cancer lineages are TRAJ31, CCL3, and KIF2B. Each is linked with PPAT in more than 2 cancer types. Because this analysis shows association rather than direction, both PPAT-to-partner and partner-to-PPAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ31 grouped by PPAT-low versus PPAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPAT→partner) and Y-score (partner→PPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ31 →	+0.563	+1.775	.001	.004	3	3
UCEC	CCL3 →	+1.109	+2.280	<.001	.001	3	2
LUSC	KIF2B →	+0.222	+4.706	<.001	.007	3	2
COAD	RPL26P3 →	+0.244	+2.847	<.001	.007	3	2
LIHC	RNU7-193P →	+0.573	+5.268	<.001	.006	3	2
COAD	MDH1P2 →	+0.088	+2.885	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,217 associations by consensus.

TRAJ31 by PPAT expression — UCEC

Explore this box plot interactively →