PPAT

Across TCGA patient cohorts, PPAT mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPAT-associated genes across cancer lineages are MEK1, MSH2, and PCNA. Each is linked with PPAT in more than 1 cancer types. Because this analysis shows association rather than direction, both PPAT-to-partner and partner-to-PPAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PPAT-low versus PPAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPAT→partner) and Y-score (partner→PPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.432	+2.662	.001	<.001	3	2
UCEC	MSH2 →	-0.234	-1.973	.006	.029	3	2
UCEC	PCNA →	+0.291	+2.662	<.001	<.001	3	2
UCEC	ATM →	-0.683	-3.687	<.001	.001	3	2
UCEC	Bad_pS112 →	-0.199	-2.308	.004	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.845	+2.827	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MEK1 by PPAT expression — UCEC

Explore this box plot interactively →