PPARGC1B

Across TCGA cell cohorts, PPARGC1B mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPARGC1B-associated genes across cancer lineages are DPRX, ZNF831, and UBTFL1. Each is linked with PPARGC1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPARGC1B-to-partner and partner-to-PPARGC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by PPARGC1B-low versus PPARGC1B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARGC1B→partner) and Y-score (partner→PPARGC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DPRX →	+0.066	+5.369	<.001	.004	3	2
BLOOD_Leukemia	ZNF831 →	+0.577	+3.807	<.001	.001	3	2
SOFT_TISSUE	UBTFL1 →	+0.043	+5.369	<.001	.004	3	1
BLOOD_Myeloma	PRORY →	+1.180	+4.807	<.001	.006	3	1
BLOOD_Myeloma	DAZ3 →	+1.563	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	RAI2 →	+0.016	+4.196	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

DPRX by PPARGC1B expression — SOFT_TISSUE

Explore this box plot interactively →