PPARGC1B

Across TCGA pan-cancer cohorts, PPARGC1B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PPARGC1B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPARGC1B RNA is repressed in tumor relative to normal tissue. In most cancer types PPARGC1B is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where PPARGC1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPARGC1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−1.052	<.001	11	view →
KIRC	Female	All	+0.573	<.001	11	view →
LUAD	Female	III,IV	−1.197	<.001	9	view →
LIHC	All	III,IV	+0.485	<.001	9	view →
BLCA	Male	IV	−2.052	<.001	8	view →
READ	All	All	−1.165	<.001	7	view →
UCEC	All	All	−0.902	<.001	6	view →
BRCA	All	III,IV	−0.816	<.001	6	view →
PRAD	All	All	−0.539	<.001	2	view →
LUSC	All	All	−0.272	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PPARGC1B–COAD

Open the COAD breakdown →