PPARG

Across TCGA cell cohorts, PPARG mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPARG-associated genes across cancer lineages are OR11H6, FTMT, and RBMY1D. Each is linked with PPARG in more than 1 cancer types. Because this analysis shows association rather than direction, both PPARG-to-partner and partner-to-PPARG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by PPARG-low versus PPARG-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARG→partner) and Y-score (partner→PPARG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR11H6 →	+0.039	+4.930	<.001	.008	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
SOFT_TISSUE	RBMY1D →	+0.053	+5.369	<.001	.004	3	1
BLOOD_Leukemia	RBP2 →	+0.049	+4.037	<.001	.004	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	CYP39A1 →	+0.215	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR11H6 by PPARG expression — SOFT_TISSUE

Explore this box plot interactively →