PPARG

Across TCGA pan-cancer cohorts, PPARG RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PPARG’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PPARG RNA is repressed in tumor relative to normal tissue. In most cancer types PPARG is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

THCA, HNSC, and COAD are the cancer types where PPARG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPARG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−1.526	<.001	11	view →
HNSC	Female	All	−1.377	<.001	11	view →
COAD	Female	II,III,IV	−0.900	<.001	10	view →
KIRP	All	All	+0.479	<.001	10	view →
LUAD	Female	All	−1.943	<.001	8	view →
LIHC	All	II,III,IV	+1.168	<.001	7	view →
BRCA	Female	All	−2.627	<.001	6	view →
LUSC	Female	All	−2.393	<.001	6	view →
STAD	Male	II,III,IV	+1.306	.001	5	view →
PAAD	All	All	+2.577	.020	2	view →
BLCA	All	IV	+2.092	.027	2	view →
ESCA	All	II,III,IV	+1.730	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PPARG–THCA

Open the THCA breakdown →